DPH5

Once upon a time, in a human cell, There was an enzyme, oh so swell, Diphthine synthase was its name, Encoded by the DPH5 gene, what a claim! This enzyme had a special role, In the diphthamide synthesis pathway, it played a role, Diphthamide, a modified histidine so rare, Only found on translation elongation factor 2, I swear! From archaebacteria to humans, it's conserved, A target for toxins, it's observed, Diphtheria toxin and Pseudomonas exotoxin A, They halt protein synthesis, causing dismay! In yeast and Chinese hamster, this enzyme is found, Catalyzing trimethylation, oh so profound, Histidine residue on elongation factor 2, Becomes diphthine, a moiety so new! With amidation, diphthamide is complete, Different isoforms, oh what a treat, Multiple transcript variants, they abound, Diphthine synthase, a fascinating enzyme, I've found! Random page: Va linux