IL12 receptor beta 1 subunit
In a land of proteins, so grand and vast,
Lived a receptor, with a name that would last.
IL-12Rβ1, a gene so fine,
Binding to cytokines, like a sweet rhyme.
With low affinity, it bound to IL-12,
Part of a complex, it did surely delve.
A transmembrane protein, tall and strong,
Belonging to the hemopoietin receptor throng.
Oligomers it formed, with disulfide links,
Required for binding, like puzzle pieces that sync.
IL-12 and IL-23, it could both embrace,
Creating binding sites, with elegance and grace.
In patients with infections, severe and dire,
Mutations in IL12RB1, they did acquire.
Immunodeficiency, a challenge so tough,
But scientists studied, and collected enough.
Alternative splicing, creating isoforms distinct,
IL-12Rβ1, a receptor that's succinct.
A tale of proteins, in a world so vast,
IL-12Rβ1, a gene that will forever last.
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XFM-1