PI3K/Akt pathway

In a world of cells, so small and bright, There's a pathway that shines with all its might. It's called PI3K/AKT/mTOR, you see, Important for the cell cycle, as can be. PI3K activation, oh so grand, Phosphorylates and activates AKT, hand in hand. Together they dance in the plasma membrane, Creating effects that are quite the fame. CREB they activate, with a magical touch, And p27 they inhibit, oh so much. FOXO they keep in the cytoplasm, you know, While PtdIns-3ps they activate, and mTOR they show. EGF, shh, IGF-1, insulin, and CaM, These factors enhance the pathway, like a sweet jam. Leptin and insulin, they recruit with grace, For metabolic regulation, in this magical place. But PTEN, GSK3B, and HB9, They antagonize the pathway, oh my! In cancers, the pathway can be overactive, Reducing apoptosis, letting cells thrive. For adult stem cells, it's a delicate dance, Promoting growth and proliferation, a chance. Neural stem cells, they need this pathway too, To balance proliferation and differentiation, it's true. And in the world of neurons, a wondrous sight, The pathway is needed for long term potentiation, so bright. Researchers seek to understand its power, To develop therapies, like a magical flower. So let's marvel at this pathway, so grand, In the world of cells, where wonders expand. PI3K/AKT/mTOR, a magical name, Guiding cells on their journey, never the same. Random page: JUSSCANNZ